The project will be carried out in Associate Professor Pauliina Damdimopoulou’s research laboratory at the Division of Obstetrics and Gynecology at the Department of Clinical Science, Intervention and Technology of Karolinska Institutet.
Research and education at the Division of Obstetrics and Gynecology are focused on the many aspects of women’s reproductive health as well as fetal physiology and stem cell biology. Chemical health risk assessment will be performed in collaboration with Associate Professor Mattias Öberg at the Institute of Environmental Medicine.
Damdimopoulou laboratory is located at the Campus Flemingsberg and focuses on human ovarian biology and effects of toxic chemicals on fertility.
DutiesThe successful candidate will work towards the national environmental quality objective; a non-toxic environment; within a Formas-funded project wherein combination effects of endocrine disruptive chemicals are studied. Effects of phthalate mixtures on female fertility will be assessed using various cell culture models as well as clinical human tissue samples. The project combines reproductive medicine, molecular biology and chemical health risk assessment. The project requires research visits to collaborator laboratories abroad.
The successful candidate will carry out cell line, primary cell and primary human tissue culture experiments, histological analyses, RNA-seq, statistical and bioinformatics data analysis, and participate in toxicological dose-response modelling. The candidate will prepare reports, manuscripts, presentations and maintain contacts with the collaborator laboratories, as well as participate in daily laboratory duties. The employment is ongoing for one year with possibility for prolongation.
Entry requirementsQualified to be employed as a postdoctoral researcher is one who has obtained a doctorate or has equivalent scientific competence. The successful candidate must have a PhD degree in relevant life sciences, such as biology, molecular biology, biomedicine or toxicology.
We are looking for a person with solid background in i) primary cell culture, ii) gene expression analysis, iii) basic molecular biology methods (e.g. immunostainings, fluorescence microscopy, isolation and analysis of nucleic acids and proteins) iv) statistical data analysis, and v) dissemination of scientific data.
We consider the following as significant merits. Experience of:
- bioinformatics and transcriptomics
- toxicological dose-response modelling
- chemical health risk assessment
- reproductive biology and ovarian function
- clinical patient sample handing and analysis
The research environment is international, and the project involves tight collaboration with several other research groups and clinicians. Fluent spoken and written English is therefore a necessity, as well as good social skills. The project will also require meticulous documentation, and the candidate must have a detailed, careful and well-organized work ethic.
Finally, the successful candidate must be self-driven and motivated, able to work independently and in a team, and capable of trouble shooting and coordinating work between different laboratories. We put great emphasis on personal qualities in the selection of candidates.
Application processAn employment application must contain the following documents in English or Swedish:
- Cover letter stating the motivation to apply and key skills that match the profile
- A complete curriculum vitae, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work (no more than two pages)
- A complete list of publications
- A summary of current work (no more than one page)
The application is to be submitted through the Varbi recruitment system.
Karolinska Institutet is one of the world’s leading medical universities. Its vision is to significantly contribute to the improvement of human health. Karolinska Institutet accounts for the single largest share of all academic medical research conducted in Sweden and offers the country’s broadest range of education in medicine and health sciences. The Nobel Assembly at Karolinska Institutet selects the Nobel laureates in Physiology or Medicine.
Pursuant to the regulations of the Swedish National Archives, applications are kept on file for two years after the appointment has gained legal force. The regulations do not apply to attachments that have been printed or otherwise published.
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