We are seeking a highly motivated, academically excellent and proactive Postdoctoral Researcher with a strong background in mass spectrometry-based proteomics and innate immunity to study inflammasome biology in health and disease. The successful candidate will participate in the collaborative project with the aim to analyse the regulation and complex assembly of inflammasome using mass spectrometry approach in combination with immunological techniques between the Härtlova lab (https://wcmtm.gu.se/research-groups/hartlova-group) and the Wick lab (https://biomedicine.gu.se/ominst/avd/mikrobio/forskare/mary-jo-wick) at the Department of Microbiology and Immunology, Institute of Biomedicine at the University of Gothenburg.
Subject areaMass spectrometry specialist in inflammasome research
Subject area descriptionUpon activation, the inflammasome rapidly forms a highly dense multiprotein complex that we can biochemically isolate and characterize. The molecular mechanisms of aggregation, the composition of the protein complex and its integration into cellular structures, the mode of activation of the present zymogens, as well as the mechanisms of the ensuing unconventional secretion of IL-1beta remain elusive. The successful candidate will investigate different facets of inflammasome biology in human IBD patient-derived epithelial and innate immune cells. The long-term goal of our work is to understand the underlying mechanisms of inflammasome activity in specific cell types in the human intestine in order to identify new avenues for IBD therapy.
Job assignmentsThe successful appointee will have the opportunity to develop their research career in a laboratory with a strong emphasis on training and mentorship. There will be opportunities to for the successful appointee to supervise postgraduate students and to apply for their own research funding.
EligibilityAn achieved doctoral degree is compulsory for a position as postdoctor at Göteborg University. The doctoral thesis shall be in a relevant area according to the specific position stated here. Since a position as postdoctor aims to give new holders of the doctorate the opportunity mainly to strengthen and develop their scholarly proficiency, we aim for those who have a doctoral degree not older than 3 years counting from last date of application.
The qualifications for academic positions are given in Chapter 4, Section 3 - 4 of the Higher Education Ordinance.
AssessmentApplicants should possess a PhD and a strong track record in mass spectrometry-based proteomics and innate immunity. Experience with the quantitative LC-MS/MS sample preparation, analysis and bioinformatics evaluation are required. Proficiency with biochemistry (Western blotting, immunoprecipitation, mass spectrometry-based proteomics) and basic immunological techniques (ELISA) is a need. Applicants should possess a strong desire to develop a successful and highly-productive research career in immunological research, excellent general research skills, a strong methodological background, excellent writing abilities, and the capacity to work both independently and within a team. Fluency in spoken and written English is essential.
A broad skill base, including quantitative LC-MS/MS analysis and biochemistry (Immunoprecipitation, Western blotting) is required. Experience isolating primary macrophages and dendritic cells and preparation of human clinical samples are meriting.
Regulations for the evaluation of qualifications for academic positions are given in Chapter 4, Section 3 - 4 of the Higher Education Ordinance.
EmploymentThe employment is full time and temporary, two years, with placement at the Institute of Biomedicine. First day of employment as agreed.
For further information:Please contact Anetta Härtlova, associate senior lecturer, phone: +46 31 786 6241, e-mail: firstname.lastname@example.org
UnionsUnion representatives at the University of Gothenburg: http://www.gu.se/english/about_the_university/job-opportunities/union-representatives
How to applyIn order to apply for a position at the University of Gothenburg, you have to register an account in our online recruitment system. It is the responsibility of the applicant to ensure that the application is complete in accordance with the instructions in the job advertisement, and that it is submitted before the deadline. The selection of candidates is made on the basis of the qualifications registered in the application.
The application should contain:
- A cover letter giving a brief description of previous research experience, and a motivation to why you are applying
- A CV including a list of publications
- Proof of completed PhD
- Contact details of two references
Salary is determined on an individual basis.
Applications will be destroyed or returned (upon request) two years after the decision of employment has become final. Applications from the employed and from those who appeal the decision will not be returned.
In connection to this recruitment, we have already decided which recruitment channels we should use. We therefore decline further contact with vendors, recruitment and staffing companies.