The Institute of Biomedicine is involved in both research and education. In both of these areas, we focus on fundamental knowledge of the living cell – what it consists of, how it works, how its function is directed by the genetic material, and how it interacts with various kinds of micro-organisms. Using this knowledge, we try to elucidate the causes of diseases, and find new ways to diagnose and treat them. At present, the institute has about 380 employees and approximately 400 million SEK in total assets. The Institute is composed of the following five departments: the Department of Infectious Diseases, the Department of Microbiology and Immunology, the Department of Pathology and Genetics, the Department of Clinical Chemistry and Transfusion Medicine and the Department of Medical Biochemistry and Cell Biology.
Dr. Clausen’s research group is interested in elucidating the molecular mechanism of genome instability and DNA repair. In particular, we are interested in understanding how DNA lesions and mutations are generated and repaired on a genome-wide, strand specific scale at single nucleotide resolution level using CRISPR/Cas9. The group will use interdisciplinary approaches to map and characterize DNA lesions and mutations in yeast, human cells and in patients with genetic diseases or cancer.
Clausen AR, Lujan SA, Burkholder AB, Orebaugh CD, Williams JS, Clausen MF, Malc EP, Mieczkowski PA, Fargo DC, Smith DJ, Kunkel TA. Tracking DNA replication in vivo using ribonucleotides. Nat. Struct. Mol. Biol. 2015; 22:185-91. PMID: 25622295.
Berglund AK, Navarrete C, Engqvist MK, Hoberg E, Szilagyi Z, Taylor RW, Gustafsson CM, Falkenberg M, Clausen AR. Nucleotide pools dictate the identity and frequency of ribonucleotide incorporation in mitochondrial DNA. PLoS Genet. 2017. 16;13(2):e1006628. PMID: 28207748.
Wanrooij PH, Engqvist MKM, Forslund JME, Navarrete C, Nilsson AK, Sedman J, Wanrooij S, Clausen AR, Chabes A. Ribonucleotides incorporated by the yeast mitochondrial DNA polymerase are not repaired. Proc Natl Acad Sci U S A. 2017;114(47):12466-12471. PMID: 29109257
Cultivating cells and isolate DNA. Construct DNA libraries for Next-Gen sequencing. Planning, executing and reporting research projects.
The applicant must hold a PhD and have experience in cell- and molecular biology. It is preferred that applicants have experience with Next-Gen sequencing technology and has experience with CRISPR/Cas9.
The employment is limited (temporary) for 12 months and full-time with placement at the Institute of Biomedicine. First day of employment as agreed.
For further information regarding the position
Please contact Postdoctoral Research Fellow Anders R. Clausen. E-mail: email@example.com
Union representatives at the University of Gothenburg: http://www.gu.se/english/about_the_university/job-opportunities/union-representatives
How to apply
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The application should contain proof of completed PhD.
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