Subject areaThe position is in clinical metabolomics studies in traumatic brain injury, with the primary focus on mining of multi-modal and multivariate data in order to develop diagnostic models for determining severity of TBI and to predict patient outcomes.
BackgroundEU project CENTER-TBI currently collects clinical data including patient records, files of imaging workup as well as blood samples from patients having suffered TBI of various severity from 60 sites of 20 EU countries. Detailed analysis and clinical and biological data banking is aimed in case of 5400 patients.
In a recently funded VR project, we aim to apply metabolic profiling of serum in CENTER-TBI prospective cohort of TBI patients to study the utility of the existing as well as to identify novel biomarkers of TBI which are also predictive of patient outcomes. These studies will be complemented by functional studies aiming to elucidate the underlying metabolic pathways in TBI.
Selected publications by the research team, relevant to the project:
Dickens AM, et al. Serum Metabolites Associated with Computed Tomography Findings after Traumatic Brain
Injury. J Neurotrauma. 2018; 35(22): 2673-2683.
Orešic M, et al. Human Serum Metabolites Associate With Severity and Patient Outcomes in Traumatic Brain Injury. EBioMedicine. 2016 Oct;12:118-126
Duties and responsibilitiesThe appointment as a postdoctoral researcher is intended to enable persons who have recently been awarded their doctoral degree, to consolidate and develop primarily their research/artistic skills. [
The researcher will be a key person in the VR project entitled ' Blood-based metabolomics to predict severity and patient outcomes in traumatic brain injury'. In close collaboration with the CENTER-TBI project and our collaborators at Universities of Cambridge and Turku, and metabolomics laboratory at Örebro University (Prof. Tuulia Hyötyläinen), the researcher will be responsible for the analysis and interpretation of prospective clinical metabolomics data from TBI patients, integrate the data with other modalities such as neuroimage and neurocognitive data, and to develop and validate statistical models to determine severity of TBI and to predict patient outcomes.
The researcher will also be involved in planning of metabolomics experiments at Örebro University.]
EligibilityEligible for the appointment as postdoctoral researcher are applicants holding a doctoral degree in metabolomics, systems biology, bioinformatics, machine learning or in related subject areas. The doctoral degree should have been awarded no more than three years prior to the application deadline. Candidates who have obtained their doctoral degree prior to that may however also be considered if special grounds exist (leave of absence due to illness, parental leave, clinical duties, an elected position in a trade union, or other similar circumstances).
Assessment criteriaGeneral assessment criteria include good interpersonal skills and an ability to cooperate as well as the ability and suitability otherwise required to perform the duties well. Particular importance shall be attached to the qualities enabling the candidate to contribute to the future development of both research and education. A demonstrated ability and desire to pursue an academic career is also of importance.
Documented knowledge and experience in biochemistry, biostatistics and statistical learning, involving analysis of biological multi-modal and multivariate data is a requirement. Experience with medical applications of metabolomics, particularly in the domains of traumatic brain injury and degenerative brain diseases, and metabolic research in general are merits. The applicant should be proficient in the R statistical language. The successful candidate should be creative, have the ability to both co-operate and independently work with research questions. Proficiency in written and spoken English is a requirement.
InformationThe position is a position for a fixed term of two years. The salary depends on the successful candidate’s qualifications and experience.
For more information, please contact Matej Orešic: +46-76-9464459, firstname.lastname@example.org
ApplicationThe application is made online. Click the button “Apply” to begin the application procedure.
For the application to be complete, the following electronic documents must be included:
- A covering letter, outlining how you believe you can contribute to the continued development of Örebro University
- CV with a relevant description of your overall qualifications and experience
- An account of research/artistic qualifications
- Copies of relevant course/degree certificates and references verifying eligibility and criteria met
- Scientific publications for consideration (maximum of 10) (Not only publication list.)
The application deadline is 31.12.2018. We look forward to receiving your application!
We decline any contact with advertisers or recruitment agencies in the recruitment process.
As directed by the National Archives of Sweden (Riksarkivet), Örebro University is required to deposit one file copy of the application documents, excluding publications, for a period of two years after the appointment decision has gained legal force.